I myself am having the same problem, long time MQ user new member here, so not quite sure whats going on with this one.
Using just the default load at the moment trying to figure out which one is causing the problems. Not sure yet, anyone else having this issue?
Also it seems to be happening while just standing around, I logged on just now, didn't use any of the macroquest utilities, jsut minimized my windows and said hi to my guild, started running, game crashed shortly after I crossed half the zone. Happened in Dawnshroud peaks.