I don't use it (yet), but both EQ and EQ2 are listed in the pre-supported game template list. Not sure what templates they have, but with the ability to use custom voice commands, I'm sure you could easily do some nifty stuff:
"Evac!" --> /cast "Succor"
"Quarken is a noob" --> /tar Quarken; /cast "Granvida Rk. III"
"Buff" --> /rt; /pause 10; /tt Inc buffs, /cast whatever
Not sure whether they only support binding keys to commands (Tab, Ctrl+Shift+up, whatever), or whether you can use more advanced things like /cast, /gate, etc. With custombind I'm sure you could do even fancier things. Going to dl the free trial now.