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Vista works great for me, Think the problem a lot of people are having with it is using older hardware. 1 thing for sure need a beefy PC to run it smoothly. Be sure to disable that annoying UAP, and get the ultimate edition ..the animated desktop is sweet.
Anyway on with the tweaks
Use ReadyBoost.
There’s been a lot of talk about Vista’s ability to use Flash drives to “boost” system performance. Traditionally, Windows will cache files both to system memory and to your hard drive. The cached files on your hard drive reside in the Page File, which is also known as “virtual memory.” The problem with this approach is that even the fastest hard drives are sluggish when compared to flash drives, at least when it comes to seek times, which are nearly instantaneous on solid-state memory. Readyboost tries to address this situation by allowing Vista to use the Flash drive for its Page File, rather than the slow hard drive. It’s important to note that the actual Page File is still cached on the hard drive, but is being accessed from the Flash drive - which means that you're not at risk for losing your data.
So, how do you enable it? Simply insert a “Readyboost capable” Flash drive that is 1GB or larger in capacity into one of your system’s USB ports, and when the pop-up box appears asking what you want to do, scroll down to find the option, “Speed up my system using Windows ReadyBoost.” You can then specify how much space to make available on the device.
This is a hotly-contested feature in Vista as some users claim a decent performance gain (mostly people with less than 1GB of RAM), but others say the benefit is negligible. If you’ve got a spare USB drive laying around, why not give it a shot? We didn't notice a profound difference in performance, but that doesn't necessarily mean that you won't.
Turn off unneeded Windows features.
Click Start, Control Panel, then under Programs at the bottom click “Uninstall a Program.” In the left-hand pane you’ll see “Turn Windows Features on or off.” Ba-da-boom, ba-da-bing. Uncheck whatever you don’t need.
Customize the size of desktop and file icons.
For some time, it has been possible to adjust font size in office documents and Web browsers simply by holding down the CTRL key while rolling your mouse wheel up and down. In Vista, the same action lets you tweak the size of your desktop icons. Just click on an empty area of the desktop, hold down CTRL, and spin your mouse wheel until the icons are the size you want. You can also adjust the size of your file or folder icons in Windows Explorer by doing the same thing. This is extremely handy for viewing thumbnails of images.
Increase SATA drive performance.
This tip “enhances” drive performance by allowing the drive in question to perform more write caching to system memory. The danger is if your system loses power and you do not have a backup power source (UPS), whatever data is cached to system memory will be lost. If you’re the adventurous type and want a bit more responsiveness out of your system, click Start, type Device Manager in the Search box, click the Device Manager, open up the Disk drives tree, right-click a drive, and select Properties. Go to the Policies tab and check “Enable Advanced Performance.” Click OK.
also visit -http://www.tweakvista.com/
-http://www.hardforum.com/showthread.php?t=1065219
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